What Are Salmon DNA Injections?

Salmon DNA injections use polynucleotides to stimulate the skin’s cellular repair processes.

“Salmon DNA injections” sounds odd until you understand the science. The treatment uses polynucleotides, long chains of DNA fragments extracted from salmon, to stimulate cellular repair at the dermal level.

If you have been reading about Rejuran treatments in Adelaide or stumbled across the term “salmon sperm facial”, this article explains exactly what the treatment involves, how it works, who it suits and what the realistic expectations are. Advanced Cosmetic Medicine in Kent Town offers Rejuran as part of its skin rejuvenation options under full medical oversight.

Where Does the Salmon DNA Actually Come From?

The DNA used in these injections is extracted from salmon milt, the reproductive cells of salmon. That is why you will sometimes hear it called a “salmon sperm injection”. The name is technically accurate but undersells the science.

Salmon DNA shares a close structural similarity to human DNA. Researchers found that polynucleotides (PNs) extracted from salmon have strong biocompatibility with human tissue, meaning the body does not reject them the way it might with synthetic materials.

The biocompatibility of salmon-derived polynucleotides makes them useful in medicine.

Researchers distinguish between two forms of the extracted DNA. PDRN (polydeoxyribonucleotide) consists of shorter DNA fragments that have been used in wound healing and regenerative medicine since the 1990s.

Polynucleotides (PNs) are longer chains with a broader regenerative profile. Rejuran uses PNs, though both forms activate similar repair pathways in the skin.

Rejuran is one of the most recognised brands using this technology and the product used at Advanced Cosmetic Medicine in Adelaide.

How Do Polynucleotides Repair Skin?

Polynucleotides work differently from fillers or anti-wrinkle injections. Rather than adding volume or freezing muscle movement, they signal your skin cells to repair themselves at the cellular level, acting on fibroblasts and keratinocytes.

Research published in the International Journal of Molecular Sciences found that PDRN acts as an A2A adenosine receptor agonist, meaning it activates a specific pathway that reduces inflammation and promotes tissue regeneration (Irrera et al., 2020). A separate study demonstrated that PDRN improves skin regeneration through differential ERK signalling in both keratinocytes and fibroblasts (Shin et al., 2023).

• Fibroblast stimulation encourages your skin to produce more collagen and elastin over time
• Anti-inflammatory action through the A2A receptor pathway may help calm irritated or damaged skin
• Improved hydration as the skin’s water-retention capacity can increase with healthier cell function
• Pigmentation regulation, with PDRN showing anti-melanogenesis properties in research (Noh et al., 2016)

The repair happens gradually. The skin is rebuilding its own structure, which takes weeks to months.

What Can Salmon DNA Injections Treat?

Rejuran is used for overall skin quality improvement rather than targeting one specific wrinkle. The treatment may suit a range of concerns, particularly where the skin has lost its ability to regenerate effectively. Adelaide’s high UV exposure contributes to many of these conditions.

• Fine lines and early signs of skin ageing
• Rough or uneven skin texture
• Enlarged pores
• Dull skin that lacks tone or clarity
• Dehydrated skin that does not respond to topical products alone
• Mild acne scarring and post-inflammatory marks
• Skin laxity in the face, neck or under-eye area

For deeper acne scarring, the clinic may recommend combining Rejuran with other treatments such as CO2 laser resurfacing for a more targeted approach. If your primary concern is persistent pigmentation such as sun spots or uneven tone, the clinic can advise whether Rejuran alone or a combination approach is more suitable.

How Does Rejuran Compare to Skin Boosters?

Both use injections into the dermis. That is where the similarity ends.

Some practitioners recommend using both in a treatment plan, spacing them apart so each can work through its own pathway. For a closer look at the differences, read our guide to what skin boosters are and how they work.

What Happens During a Rejuran Session?

A typical session at the clinic takes roughly 30 to 45 minutes, including preparation time. Here is what to expect if you book at Advanced Cosmetic Medicine’s Kent Town clinic in Adelaide.

1. Consultation first. The practitioner assesses your skin, discusses your concerns and determines whether Rejuran is appropriate for you.
2. Topical anaesthetic applied. A numbing cream is applied to the treatment area and left for 15 to 20 minutes to take effect.
3. Injection. Small amounts of the polynucleotide solution are injected into the dermis using a fine needle or cannula. The technique creates a grid of micro-deposits across the treatment area.
4. Aftercare advice. You can typically return to normal activities the same day. Avoid touching the treated area, heavy exercise and direct sun exposure for the first 24 hours.

Small raised bumps at the injection sites are normal and usually flatten within 24 to 48 hours. The treatment is performed by the clinic’s nurse or dermal therapist under the medical oversight of Dr Rahma Targett (FRACGP).

How Many Sessions and When Do Results Show?

Most treatment plans begin with three to four sessions spaced two to four weeks apart. The initial course allows the polynucleotides to accumulate in the skin and maintain the regeneration signal to your fibroblasts.

A single session can start the process, but the cumulative effect of multiple treatments is where the more noticeable changes tend to occur.

After the initial course, maintenance sessions once or twice a year can help sustain the results. The practitioner at the clinic will advise on timing based on how your skin responds.

Side Effects and Risks to Know About

Most side effects are mild and temporary. You should still know what is possible before booking.

Common (expected) reactions:

• Small raised bumps at injection sites, lasting 24 to 48 hours
• Mild redness or swelling in the treated area
• Bruising, particularly in thin-skinned areas like under the eyes
• Tenderness at injection points for the first day or two

Rare but possible:

• Allergic reaction, particularly in people with fish allergies
• Infection at the injection site (risk is minimised with proper technique and sterile conditions)
• Prolonged swelling or nodule formation

All cosmetic injectable treatments at the clinic are provided under medical oversight. Contact the clinic on (08) 8239 0431 if you have any concerns after treatment.

Who Should Think Twice About Salmon DNA Injections?

Rejuran is not for everyone. Some situations are clear contraindications; others need a proper conversation before proceeding.

• Known fish or seafood allergy. The polynucleotides are derived from salmon. If you have a confirmed fish allergy, this treatment may not be suitable. Discuss it with the practitioner before booking.
• Pregnancy or breastfeeding. As with most cosmetic injectables, Rejuran is generally not recommended during pregnancy or while breastfeeding.
• Active skin infection. Any infection, rash or open wound in the treatment area needs to resolve before the injections can go ahead.
• Blood-thinning medication. Certain medications increase bruising risk. The practitioner needs to know about any medications or supplements you are taking.
• Autoimmune conditions. Some autoimmune conditions may affect how the skin responds to the treatment. A consultation allows the practitioner to assess your individual situation.

A consultation at the clinic covers all of these points, accounting for your medical history and skin goals.

Frequently Asked Questions

Next Steps

Book a consultation at Advanced Cosmetic Medicine in Kent Town to discuss whether Rejuran is right for you. Dr Rahma Targett (FRACGP) oversees all treatment planning.

For details, visit our Rejuran treatment page or call (08) 8239 0431 to book.